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Does CBD Interact with Any Other Medications?

Does CBD Interact with Any Other Medications?

As the popularity of cannabidiol (CBD) continues to surge, so does the curiosity about its potential interactions with other medications. CBD, a natural compound found in the cannabis plant, has been lauded for its therapeutic benefits, helping alleviate symptoms of insomnia, anxiety, and chronic pain among others. However, as with any substance, it's crucial to understand how it might interact with other substances you're taking.

Understanding CBD and Its Effects

CBD is one of many chemical compounds found in cannabis. Unlike its more famous cousin, THC, CBD does not have psychoactive effects, meaning it doesn't alter your state of mind or make you feel "high." Instead, it's the therapeutic effects of CBD that have made it a popular choice for many.

However, it's important to note that while CBD is generally considered safe with few minor side effects, it does have the potential to interact with other medications. This interaction primarily has to do with how the body metabolizes substances.

How the Body Metabolizes Substances

When you take a medication or other substance, your body has to metabolize it, or break it down. This process of drug metabolism occurs throughout the body, but the liver plays a significant role. A family of enzymes known as cytochrome P450 (CYP450) is responsible for converting foreign substances so they can be easily eliminated from the body.

However, some medications or substances can affect CYP450, either by slowing or speeding up drug metabolism. This change in metabolism rate can alter how your body processes the medications or supplements you take, leading to a drug interaction.

The Role of CYP450 in CBD and Medication Interactions

The Role of CYP450 in CBD and Medication Interactions

The CYP450 family of enzymes is responsible for metabolizing several cannabinoids, including CBD. Specifically, an enzyme within the CYP450 family called CYP3A4 is tasked with this job. However, CBD can interfere with CYP3A4, affecting its ability to break down medications effectively.

CYP3A4 is responsible for metabolizing about 60 percent of clinically prescribed medications. If CBD inhibits CYP3A4, it can't work as effectively to break down the medications in your system. This can lead to higher concentrations of the medication in your bloodstream, potentially exaggerating its effects, including unwanted or harmful side effects.

Conversely, many medications inhibit CYP3A4. If you take CBD while on these medications, your body can't process the CBD as effectively. This could result in having more CBD in your system than intended, which could amplify its effects.

Specific Medications That May Interact with CBD

Specific Medications That May Interact with CBD

While CBD can potentially interact with a wide range of medications due to its effect on the CYP450 enzyme system, there are certain classes of medications that warrant particular attention.

Antiepileptic Drugs

CBD is often used in conjunction with antiepileptic drugs, but it's known to interact with several of them. Certain antiepileptic drugs, including carbamazepine, oxcarbazepine, phenobarbital, and phenytoin, can affect the metabolism of CBD, leading to decreased levels of CBD. This can ultimately reduce the effectiveness of CBD.

Moreover, combining CBD with Depakote (valproic acid or valproate) can lead to abnormally high liver enzyme levels, indicating potential liver problems. Patients using CBD with these antiepileptic drugs should be monitored for liver disease or injury.


CBD can block the actions of the CYP2D6 enzyme, which can result in decreased metabolism and increased blood levels of certain antidepressants, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). This interaction can lead to increased side effects of antidepressants.


CBD can alter the metabolism of benzodiazepines, which are prescription drugs used to treat insomnia, anxiety, or seizures. In particular, the use of CBD can increase blood levels of several benzodiazepines, including clobazam, diazepam, and lorazepam, which can lead to increased side effects of these benzodiazepines.

Opioid Analgesics

Potential interactions exist between CBD and opioid pain relievers. For instance, CBD can decrease the metabolism of morphine, which may lead to increased blood levels and side effects of morphine.

Blood Thinners

The use of CBD can also alter the metabolism of different blood thinners, including anticoagulants and antiplatelet agents. Taking CBD with warfarin may lead to an increased risk of bleeding.


CBD can increase the blood levels of immunosuppressants like tacrolimus and cyclosporine, leading to toxic levels of immunosuppressants and increased side effects.

Proton Pump Inhibitors

Proton pump inhibitors (PPIs), such as omeprazole, pantoprazole, and lansoprazole, are processed by the CYP enzymes. As CBD use can interfere with the function of the CYP enzymes, mixing CBD and PPIs could lead to increased side effects of PPIs.

Herbal and Dietary Supplements

Some herbal and dietary supplements, such as St. John’s wort, can alter the metabolism of CBD. Taking St. John’s wort with CBD can lead to decreased blood levels and reduced effects of CBD.

Who is Most at Risk for CBD Interactions?

Certain individuals may be at a higher risk of drug-drug interactions involving CBD than others. Older adults and people taking multiple medications are more likely to experience an interaction while taking CBD.

Older adults are more likely to experience drug-drug interactions than younger adults because they have a greater risk of kidney or liver problems. As CBD is processed in the liver, along with many other medications, older adults may be at an increased risk of high drug levels in the body and adverse effects.

People who take several medications are at a greater risk of drug interactions. Different medications can influence or alter how other medications are processed. Side effects of medications can also overlap, which can lead to serious complications. It’s important to use caution before mixing CBD and multiple medications, especially if you have multiple health conditions.

Consulting Your Doctor Before Trying CBD

Given the potential for CBD to interact with other medications, it's crucial to consult your doctor before trying CBD. They can help determine a safe dosage and schedule that won't interfere with your current medications. In some cases, your doctor may want to monitor blood plasma levels of certain medications you're taking.

It's important to note that you should not stop taking your prescription medications to try CBD unless your doctor gives you the go-ahead.


The world of CBD is a fascinating one, offering potential relief for a variety of ailments from anxiety to chronic pain. However, as with any substance, it's crucial to understand how it interacts with other medications you may be taking. The interaction between CBD and other medications primarily revolves around the CYP450 enzyme system in the liver, which is responsible for metabolizing a significant portion of drugs used clinically.

While CBD is generally considered safe and well-tolerated, it can interact with a wide range of medications, including antiepileptic drugs, antidepressants, benzodiazepines, opioid analgesics, blood thinners, immunosuppressants, proton pump inhibitors, and even certain herbal and dietary supplements. These interactions can lead to increased side effects, altered drug effectiveness, and potential health risks.

Particular caution should be exercised by older adults and individuals taking multiple medications, as they are at a higher risk of experiencing CBD-drug interactions. Therefore, it's essential to consult with a healthcare provider before starting CBD, especially if you're taking other medications. They can provide guidance on safe dosages and schedules, and monitor any potential interactions with your current medications.

In conclusion, while the therapeutic potential of CBD is significant, it's not without its complexities. As research continues to unfold, it's crucial to approach CBD use with an informed perspective, understanding its potential interactions with other medications, and always consulting with a healthcare provider to ensure safe and effective use.

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